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| http://purl.uniprot.org/citations/16725108 | http://www.w3.org/2000/01/rdf-schema#comment | "B and T lymphocyte attenuator (BTLA) is a recently identified inhibitory receptor expressed by B and T cells. We previously identified two tyrosine-containing signaling motifs in the cytoplasmic domain of BTLA that interact with the SHP-1 and SHP-2 phosphatases. BTLA has a third conserved tyrosine-containing motif within the cytoplasmic domain, similar in sequence to a Grb-2 recruitment site. To identify specific interacting proteins that would be recruited to this motif, we carried out an unbiased screen by using synthetic peptides in active (e.g., phosphotyrosil-containing) or control (e.g., non-phosphorylated) forms as baits. Using mass spectrometry, we identified two specific interacting proteins, Grb-2 and the p85 subunit of PI3K. Further, we demonstrate that the interaction with Grb-2 is direct, whereas the recruitment of the p85 subunit by BTLA phosphotyrosile-containing peptides may be indirect via its association with Grb-2. These findings may provide biochemical basis for previously unexplained actions of BTLA."xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.05.036"xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/author | "Gavrieli M."xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/pages | "1440-1445"xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/title | "Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA."xsd:string |
| http://purl.uniprot.org/citations/16725108 | http://purl.uniprot.org/core/volume | "345"xsd:string |
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