| http://purl.uniprot.org/citations/16728402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16728402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16728402 | http://www.w3.org/2000/01/rdf-schema#comment | "Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. There are three consensus glucocorticoid/androgen response elements and four Sp1-binding sites in the human monoamine oxidase A 2-kb promoter. A novel transcription factor R1 (RAM2/CDCA7L) interacts with Sp1-binding sites and represses MAO A gene expression. Luciferase assays show that glucocorticoid (dexamethasone) and androgen (R1881) increase MAO A promoter and catalytic activities in human neuroblastoma and glioblastoma cells. Gel-shift analysis demonstrates that glucocorticoid/androgen receptors interact directly with the third glucocorticoid/androgen response element. Glucocorticoid/androgen receptors also interact with Sp1-binding sites indirectly via transcription factor Sp1. In addition, dexamethasone induces R1 translocation from the cytosol to the nucleus in a time-dependent manner in both the neuroblastoma and wild-type UW228 cell lines but not in R1 knock-down UW228 cells. In summary, this study shows that glucocorticoid enhances monoamine oxidase A gene expression by 1) regulation of R1 translocation; 2) direct interaction of the glucocorticoid receptor with the third glucocorticoid/androgen response element; and 3) indirect interaction of glucocorticoid receptor with the Sp1 or R1 transcription factor on Sp1-binding sites of the MAO A promoter. Androgen also up-regulates MAO A gene expression by direct interaction of androgen receptor with the third glucocorticoid/androgen response element. Androgen receptor indirectly interacts with the Sp1, but not R1 transcription factor, on Sp1-binding sites. This study provides new insights on the differential regulation of MAO A by glucocorticoid and androgen."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m600250200"xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m600250200"xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/author | "Shih J.C."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/author | "Shih J.C."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/author | "Ou X.-M."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/author | "Ou X.-M."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/pages | "21512-21525"xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/pages | "21512-21525"xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/title | "Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/title | "Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1."xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16728402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16728402 |
| http://purl.uniprot.org/citations/16728402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16728402 |
| http://purl.uniprot.org/citations/16728402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16728402 |
| http://purl.uniprot.org/citations/16728402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16728402 |