| http://purl.uniprot.org/citations/16731946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16731946 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-I that plays an essential role in signaling to the host antiviral response. Recently, the adapter molecule that links RIG-I sensing of incoming viral RNA to downstream signaling and gene activation events was characterized by four different groups; MAVS/IPS-1-1/VISA/Cardif contains an amino-terminal CARD domain and a carboxyl-terminal mitochondrial transmembrane sequence that localizes to the mitochondrial membrane. Furthermore, the hepatitis C virus NS3-4A protease complex specifically targets MAVS/IPS-1/VISA/Cardif for cleavage as part of its immune evasion strategy. With a novel search program written in python, we also identified an uncharacterized protein, KIAA1271 (K1271), containing a single CARD-like domain at the N terminus and a Leu-Val-rich C terminus that is identical to that of MAVS/IPS-1/VISA/Cardif. Using a combination of biochemical analysis, subcellular fractionation, and confocal microscopy, we now demonstrate that NS3-4A cleavage of MAVS/IPS-1/VISA/Cardif/K1271 results in its dissociation from the mitochondrial membrane and disrupts signaling to the antiviral immune response. Furthermore, virus-induced IKKepsilon kinase, but not TBK1, colocalized strongly with MAVS at the mitochondrial membrane, and the localization of both molecules was disrupted by NS3-4A expression. Mutation of the critical cysteine 508 to alanine was sufficient to maintain mitochondrial localization of MAVS/IPS-1/VISA/Cardif and IKKepsilon in the presence of NS3-4A. These observations provide an outline of the mechanism by which hepatitis C virus evades the interferon antiviral response."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02495-05"xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Wilkinson P."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Hiscott J."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Vitour D."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Julkunen I."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Meurs E."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Lacoste J."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Nakhaei P."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/author | "Paz S."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/pages | "6072-6083"xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/title | "Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage."xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/16731946 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16731946 |
| http://purl.uniprot.org/citations/16731946 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16731946 |
| http://purl.uniprot.org/uniprot/#_A0A075B7B4-mappedCitation-16731946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16731946 |
| http://purl.uniprot.org/uniprot/#_Q14164-mappedCitation-16731946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16731946 |
| http://purl.uniprot.org/uniprot/#_Q7Z434-mappedCitation-16731946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16731946 |
| http://purl.uniprot.org/uniprot/Q7Z434 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16731946 |