| http://purl.uniprot.org/citations/16738336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16738336 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectin 3 (Gal-3), a member of the beta-galactoside binding lectin family, exhibits antiapoptotic functions, and its aberrant expression is involved in various aspects of tumor progression. Here we show that p53-induced apoptosis is associated with transcriptional repression of Gal-3. Previously, it has been reported that phosphorylation of p53 at Ser46 is important for transcription of proapoptotic genes and induction of apoptosis and that homeodomain-interacting protein kinase 2 (HIPK2) is specifically involved in these functions. We show that HIPK2 cooperates with p53 in Gal-3 repression and that this cooperation requires HIPK2 kinase activity. Gene-specific RNA interference demonstrates that HIPK2 is essential for repression of Gal-3 upon induction of p53-dependent apoptosis. Furthermore, expression of a nonrepressible Gal-3 prevents HIPK2- and p53-induced apoptosis. These results reveal a new apoptotic pathway induced by HIPK2-activated p53 and requiring repression of the antiapoptotic factor Gal-3."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00959-05"xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Soddu S."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Bartolazzi A."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Trovato M."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Piaggio G."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Cecchinelli B."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Rinaldo C."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Iacovelli S."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Sciacchitano S."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Gasbarri A."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Gurtner A."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Lavra L."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Del Prete F."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/author | "Ulivieri A."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/pages | "4746-4757"xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/title | "Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/16738336 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16738336 |
| http://purl.uniprot.org/citations/16738336 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16738336 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-16738336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16738336 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-16738336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16738336 |