| http://purl.uniprot.org/citations/16751101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751101 | http://www.w3.org/2000/01/rdf-schema#comment | "TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. TGFbeta responses are generally mediated through transcriptional functions of Smads. A key step in TGFbeta signaling is ligand-induced phosphorylation of receptor-activated Smads (R-Smads) catalyzed by the TGFbeta type I receptor kinase. However, the potential of Smad dephosphorylation as a regulatory mechanism of TGFbeta signaling and the identity of Smad-specific phosphatases remain elusive. Using a functional genomic approach, we have identified PPM1A/PP2Calpha as a bona fide Smad phosphatase. PPM1A dephosphorylates and promotes nuclear export of TGFbeta-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFbeta-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFbeta signaling in mammalian cells. Smad-antagonizing activity of PPM1A is also observed during Nodal-dependent early embryogenesis in zebrafish. This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.03.044"xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.03.044"xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Meng A."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Meng A."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Davis C.M."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Davis C.M."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Long J."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Long J."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Chen Y.G."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Chen Y.G."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Duan X."xsd:string |
| http://purl.uniprot.org/citations/16751101 | http://purl.uniprot.org/core/author | "Duan X."xsd:string |