| http://purl.uniprot.org/citations/16751180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751180 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the CSA or CSB complementation genes cause the Cockayne syndrome, a severe genetic disorder that results in patients' death in early adulthood. CSA and CSB act in a transcription-coupled repair (TCR) pathway, but their functional relationship is not understood. We have previously shown that CSA is a subunit of an E3 ubiquitin ligase complex. Here we demonstrate that CSB is a substrate of this ligase: Following UV irradiation, CSB is degraded at a late stage of the repair process in a proteasome- and CSA-dependent manner. Moreover, we demonstrate the importance of CSB degradation for post-TCR recovery of transcription and for the Cockayne syndrome. Our results unravel for the first time the functional relationship between CSA and CSB."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.378206"xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.378206"xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Kisselev A.F."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Kisselev A.F."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Groisman R."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Groisman R."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Magnaldo T."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Magnaldo T."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Kuraoka I."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Kuraoka I."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Harel-Bellan A."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Harel-Bellan A."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Chevallier O."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Chevallier O."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Gaye N."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/author | "Gaye N."xsd:string |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16751180 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |