| http://purl.uniprot.org/citations/16751407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751407 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids promote macrophage phagocytosis of leukocytes undergoing apoptosis. Prereceptor metabolism of glucocorticoids by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) modulates cellular steroid action. 11beta-HSD type 1 amplifies intracellular levels of active glucocorticoids in mice by reactivating corticosterone from inert 11-dehydrocorticosterone in cells expressing the enzyme. In this study we describe the rapid (within 3 h) induction of 11beta-HSD activity in cells elicited in the peritoneum by a single thioglycolate injection in mice. Levels remained high in peritoneal cells until resolution. In vitro experiments on mouse macrophages demonstrated that treatment with inert 11-dehydrocorticosterone for 24 h increased phagocytosis of apoptotic neutrophils to the same extent as corticosterone. This effect was dependent upon 11beta-HSD1, as 11beta-HSD1 mRNA, but not 11beta-HSD2 mRNA, was expressed in these cells; 11-dehydrocorticosterone was ineffective in promoting phagocytosis by Hsd11b1(-/-) macrophages, and carbenoxolone, an 11beta-HSD inhibitor, prevented the increase in phagocytosis elicited in wild-type macrophages by 11-dehydrocorticosterone. Importantly, as experimental peritonitis progressed, clearance of apoptotic neutrophils was delayed in Hsd11b1(-/-) mice. These data point to an early role for 11beta-HSD1 in promoting the rapid clearance of apoptotic cells during the resolution of inflammation and indicate a novel target for therapy."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.12.7605"xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Harris H.J."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Mullins J.J."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Chapman K.E."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Seckl J.R."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Clay M."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Savill J.S."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Man T.Y."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Cailhier J.F."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Coutinho A.E."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/author | "Gilmour J.S."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/pages | "7605-7611"xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/title | "Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes."xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16751407 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16751407 |
| http://purl.uniprot.org/citations/16751407 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16751407 |
| http://purl.uniprot.org/uniprot/#_F2Z3U6-mappedCitation-16751407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16751407 |
| http://purl.uniprot.org/uniprot/#_F6TSI8-mappedCitation-16751407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16751407 |
| http://purl.uniprot.org/uniprot/#_P50172-mappedCitation-16751407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16751407 |
| http://purl.uniprot.org/uniprot/#_Q4JHD9-mappedCitation-16751407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16751407 |