| http://purl.uniprot.org/citations/16751418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751418 | http://www.w3.org/2000/01/rdf-schema#comment | "Target Ag display is a necessary requirement for the expression of certain immune-mediated kidney diseases. We previously had shown that anti-DNA Abs that cross-react with alpha-actinin may be important in the pathogenesis of murine and human lupus nephritis; in murine models, we had found that a significant proportion of pathogenic serum and kidney-deposited Igs are alpha-actinin reactive. Furthermore, a pathogenic anti-DNA/alpha-actinin Ab showed enhanced binding to immortalized mesangial cells (MCs) derived from a lupus prone MRL-lpr/lpr mouse as compared with MCs from BALB/c mice which are not susceptible to spontaneous lupus, suggesting that kidney alpha-actinin expression may be contributing to nephritis. In the current study, we established that two isoforms of alpha-actinin that are present in the kidney, alpha-actinin 1 and alpha-actinin 4, can both be targeted by anti-alpha-actinin Abs. We found novel sequence polymorphisms between MRL-lpr/lpr and BALB/c in the gene for alpha-actinin 4. Moreover, alpha-actinin 4 and a splice variant of alpha-actinin 1 were both expressed at significantly higher levels (mRNA and protein) in MCs from the lupus prone MRL-lpr/lpr strain. Significantly, we were able to confirm these differences in intact kidney by examining glomerular Ig deposition of anti-alpha-actinin Abs. We conclude that enhanced alpha-actinin expression may determine the extent of Ig deposition in the Ab-mediated kidney disease in lupus. Modulation of Ag expression may be a promising approach to down-regulate immune complex formation in the target organ in individuals with circulating pathogenic Abs."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.12.7704"xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Scherer P.E."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Scherer P.E."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Ozelius L.J."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Ozelius L.J."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Deocharan B."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Deocharan B."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Putterman C."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/author | "Putterman C."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/pages | "7704-7714"xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/pages | "7704-7714"xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/title | "Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/title | "Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin."xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16751418 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16751418 |