| http://purl.uniprot.org/citations/16753562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16753562 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila anterior-posterior axis is established at stage 7 of oogenesis when the posterior follicle cells signal to polarize the oocyte microtubule cytoskeleton. This requires the conserved PAR-1 kinase, which can be detected at the posterior of the oocyte in immunostainings from stage 9. However, this localization depends on Oskar localization, which requires the earlier PAR-1-dependent microtubule reorganization, indicating that Oskar-associated PAR-1 cannot establish oocyte polarity. Here we analyze the function of the different PAR-1 isoforms and find that only PAR-1 N1 isoforms can completely rescue the oocyte polarity phenotype. Furthermore, PAR-1 N1 is recruited to the posterior cortex of the oocyte at stage 7 in response to the polarizing follicle cell signal, and this requires actin, but not microtubules. This suggests that posterior PAR-1 N1 polarizes the microtubule cytoskeleton. PAR-1 N1 localization is mediated by a cortical targeting domain and a conserved anterior-lateral exclusion signal in its C-terminal linker domain. PAR-1 is also required for the polarization of the C. elegans zygote and is recruited to the posterior cortex in an actin-dependent manner. Our results therefore identify a molecular parallel between axis formation in Drosophila and C. elegans and make Drosophila PAR-1 N1 the earliest known marker for the polarization of the oocyte."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.04.001"xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/author | "St Johnston D."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/author | "Zwart M.F."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/author | "Benton R."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/author | "Doerflinger H."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/author | "Torres I.L."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/pages | "1090-1095"xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/title | "Drosophila anterior-posterior polarity requires actin-dependent PAR-1 recruitment to the oocyte posterior."xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/16753562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16753562 |
| http://purl.uniprot.org/citations/16753562 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16753562 |
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| http://purl.uniprot.org/uniprot/#_P49028-mappedCitation-16753562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16753562 |
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