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| http://purl.uniprot.org/citations/16754322 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis is a central event in the innate immune responses that are triggered by the association between ligands on the surface of pathogens and receptors on the membrane of phagocytes. Particularly, complement-mediated phagocytosis is accomplished by specific recognition of bound complement components by the corresponding complement receptors on the phagocytes. The protein-tyrosine kinase, Syk, plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system. From recent studies using a macrophage-like differentiated cell line and serum-treated zymosan, it was found that Syk also plays an essential role in complement-mediated phagocytosis in innate immunity. Serum-treated zymosan particles promptly attached to the cells and were subsequently engulfed via complement receptor3. During this process, Syk became tyrosine-phosphorylated and accumulated around the nascent phagosomes. The transfer of Syk-siRNA or dominant-negative Syk (DN-Syk) into macrophages resulted in impaired engulfment of pathogen. Collectively, Syk is required for the engulfment of pathogen in complement-mediated phagocytosis."xsd:string |
| http://purl.uniprot.org/citations/16754322 | http://purl.org/dc/terms/identifier | "doi:10.1080/15216540600746377"xsd:string |
| http://purl.uniprot.org/citations/16754322 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/16754322 | http://purl.uniprot.org/core/author | "Tohyama Y."xsd:string |
| http://purl.uniprot.org/citations/16754322 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
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| http://purl.uniprot.org/citations/16754322 | http://purl.uniprot.org/core/title | "Complement-mediated phagocytosis--the role of Syk."xsd:string |
| http://purl.uniprot.org/citations/16754322 | http://purl.uniprot.org/core/volume | "58"xsd:string |
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