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http://purl.uniprot.org/citations/16754859http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16754859http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16754859http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16754859http://www.w3.org/2000/01/rdf-schema#comment"Lactobacillus delbrueckii ssp. bulgaricus (L. bulgaricus) is a representative of the group of lactic acid-producing bacteria, mainly known for its worldwide application in yogurt production. The genome sequence of this bacterium has been determined and shows the signs of ongoing specialization, with a substantial number of pseudogenes and incomplete metabolic pathways and relatively few regulatory functions. Several unique features of the L. bulgaricus genome support the hypothesis that the genome is in a phase of rapid evolution. (i) Exceptionally high numbers of rRNA and tRNA genes with regard to genome size may indicate that the L. bulgaricus genome has known a recent phase of important size reduction, in agreement with the observed high frequency of gene inactivation and elimination; (ii) a much higher GC content at codon position 3 than expected on the basis of the overall GC content suggests that the composition of the genome is evolving toward a higher GC content; and (iii) the presence of a 47.5-kbp inverted repeat in the replication termination region, an extremely rare feature in bacterial genomes, may be interpreted as a transient stage in genome evolution. The results indicate the adaptation of L. bulgaricus from a plant-associated habitat to the stable protein and lactose-rich milk environment through the loss of superfluous functions and protocooperation with Streptococcus thermophilus."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0603024103"xsd:string
http://purl.uniprot.org/citations/16754859http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0603024103"xsd:string
http://purl.uniprot.org/citations/16754859http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0603024103"xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Barbe V."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Barbe V."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Barbe V."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Couloux A."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Couloux A."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Couloux A."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Batto J.-M."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Batto J.-M."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Batto J.-M."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bessieres P."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bessieres P."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bessieres P."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bolotin A."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bolotin A."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bolotin A."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bossy R."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bossy R."xsd:string
http://purl.uniprot.org/citations/16754859http://purl.uniprot.org/core/author"Bossy R."xsd:string