| http://purl.uniprot.org/citations/16757478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16757478 | http://www.w3.org/2000/01/rdf-schema#comment | "Correct patterning of the antero-posterior axis of the embryonic trunk is dependent on spatiotemporally restricted Hox gene expression. In this study, we identified components of the Hoxd4 P1 promoter directing expression in neurally differentiating retinoic acid-treated P19 cells. We mapped three nucleosomes that are subsequently remodeled into an open chromatin state upon retinoic acid-induced Hoxd4 transcription. These nucleosomes spanned the Hoxd4 transcriptional start site in addition to a GC-rich positive regulatory element located 3' to the initiation site. We further identified two major cis-acting regulatory elements. An autoregulatory element was shown to recruit HOXD4 and its cofactor PBX1 and to positively regulate Hoxd4 expression in differentiating P19 cells. Conversely, the Polycomb group (PcG) protein Ying-Yang 1 (YY1) binds to an internucleosomal linker and represses Hoxd4 transcription before and during transcriptional activation. Sequential chromatin immunoprecipitation studies revealed that the PcG protein MEL18 was co-recruited with YY1 only in undifferentiated P19 cells, suggesting a role for MEL18 in silencing Hoxd4 transcription in undifferentiated P19 cells. This study links for the first time local chromatin remodeling events that take place during transcriptional activation with the dynamics of transcription factor association and DNA accessibility at a Hox regulatory region."xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602555200"xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/author | "Rastegar M."xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/author | "Featherstone M."xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/author | "Kobrossy L."xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/pages | "25926-25939"xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/title | "Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation."xsd:string |
| http://purl.uniprot.org/citations/16757478 | http://purl.uniprot.org/core/volume | "281"xsd:string |
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