| http://purl.uniprot.org/citations/16757566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16757566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16757566 | http://www.w3.org/2000/01/rdf-schema#comment | "PKCepsilon has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKCepsilon in LPS signaling is unknown. LPS signaling is mediated by Toll-like receptor 4, which uses four adapter proteins, MyD88, MyD88 adapter-like (Mal), Toll/IL-1R domain-containing adapter inducing IFN-beta (Trif), and Trif-related adapter molecule (TRAM). Here we show that TRAM is transiently phosphorylated by PKCepsilon on serine-16 in an LPS-dependent manner. Activation of IFN regulatory factor 3 and induction of the chemokine RANTES, which are both TRAM-dependent, were attenuated in PKCepsilon-deficient cells. TRAMS16A is inactive when overexpressed and is attenuated in its ability to reconstitute signaling in TRAM-deficient cells. We have therefore uncovered a key process in Toll-like receptor 4 signaling, identifying TRAM as the target for PKCepsilon."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0600462103"xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0600462103"xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Gay N.J."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Gay N.J."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Golenbock D.T."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Golenbock D.T."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "O'Neill L.A.J."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "O'Neill L.A.J."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "McGettrick A.F."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "McGettrick A.F."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Brint E.K."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Brint E.K."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Rowe D.C."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Rowe D.C."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Palsson-McDermott E.M."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/author | "Palsson-McDermott E.M."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/16757566 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |