| http://purl.uniprot.org/citations/16757682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16757682 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous megakaryocyte-specific genes contain signature Ets-binding sites in their regulatory regions. Fli-1 (friend leukemia integration 1), an Ets transcription factor, is required for the normal maturation of megakaryocytes and controls the expression of multiple megakaryocyte-specific genes. However, in Fli-1-/-mice, early megakaryopoiesis persists, and the expression of the early megakaryocyte-specific genes, alphaIIb and cMpl, is maintained, consistent with functional compensation by a related Ets factor(s). Here we identify the Ets protein GABPalpha (GA-binding protein alpha) as a regulator of early megakaryocyte-specific genes. Notably, GABPalpha preferentially occupies Ets elements of early megakaryocyte-specific genes in vitro and in vivo, whereas Fli-1 binds both early and late megakaryocyte-specific genes. Moreover, the ratio of GABPalpha/Fli-1 expression declines throughout megakaryocyte maturation. Consistent with this expression pattern, primary fetal liver-derived megakaryocytes from Fli-1-deficient murine embryos exhibit reduced expression of genes associated with late stages of maturation (glycoprotein [GP] Ibalpha, GPIX, and platelet factor 4 [PF4]), whereas GABPalpha-deficient megakaryocytes were mostly impaired in the expression of early megakaryocyte-specific genes (alphaIIb and cMpl). Finally, mechanistic experiments revealed that GABPalpha, like Fli-1, can impart transcriptional synergy between the hematopoietic transcription factor GATA-1 and its cofactor FOG-1 (friend of GATA-1). In concert, these data reveal disparate, but overlapping, functions of Ets transcription factors at distinct stages of megakaryocyte maturation."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-04-019760"xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Watson D.K."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Xue H.H."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Blobel G.A."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Pang L."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Leonard W.J."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Szalai G."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/author | "Poncz M."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/pages | "2198-2206"xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/title | "Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins."xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16757682 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16757682 |
| http://purl.uniprot.org/citations/16757682 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16757682 |
| http://purl.uniprot.org/uniprot/P26323#attribution-165446703F17AD5164D0C2DC5EE672FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16757682 |
| http://purl.uniprot.org/uniprot/P26323#attribution-AD4E86608BC46E0C2F3161DB0E8841B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16757682 |
| http://purl.uniprot.org/uniprot/Q00422#attribution-165446703F17AD5164D0C2DC5EE672FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16757682 |
| http://purl.uniprot.org/uniprot/Q00422#attribution-AD4E86608BC46E0C2F3161DB0E8841B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16757682 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTR7-mappedCitation-16757682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16757682 |
| http://purl.uniprot.org/uniprot/#_E9Q7U5-mappedCitation-16757682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16757682 |