| http://purl.uniprot.org/citations/16762835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16762835 | http://www.w3.org/2000/01/rdf-schema#comment | "We report genome-wide analyses that establish Maf1 as a general and direct repressor of yeast RNA polymerase (Pol) III transcription. Chromatin immunoprecipitation (ChIP) coupled to microarray hybridization experiments showed an increased association of Maf1 to Pol III-transcribed genes under repressing condition (rapamycin treatment) correlated with a dissociation of Brf1 and Pol III. Maf1 can exist in various phosphorylation states and interacts with Pol III in a dephosphorylated state. The largest subunit of Pol III, C160, was identified as a target of Maf1. Under repressing conditions, Maf1 is dephosphorylated and accumulates in the nucleus, and Pol III-Maf1 interaction increases. Mutations in protein phosphatase type 2A (PP2A) catalytic subunit-encoding genes prevented rapamycin-induced Maf1 dephosphorylation, its nuclear accumulation, and repression of Pol III transcription. The results indicate that Pol III transcription can be globally and rapidly downregulated via dephosphorylation and relocation of a general negative cofactor."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.04.008"xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Sentenac A."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Gonzalez de Peredo A."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Boguta M."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Oficjalska-Pham D."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Lefebvre O."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Smagowicz W.J."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/author | "Harismendy O."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/pages | "623-632"xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/title | "General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1."xsd:string |
| http://purl.uniprot.org/citations/16762835 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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