| http://purl.uniprot.org/citations/16763554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16763554 | http://www.w3.org/2000/01/rdf-schema#comment | "Although p90 ribosomal S6 kinase (RSK) is known as an important downstream effector of the ribosomal protein S6 kinase/extracellular signal-regulated kinase (Ras/ERK) pathway, its endogenous role, and precise molecular function remain unclear. Using gain-of-function and null mutants of RSK, its physiological role was successfully characterized in Drosophila. Surprisingly, RSK-null mutants were viable, but exhibited developmental abnormalities related to an enhanced ERK-dependent cellular differentiation such as ectopic photoreceptor- and vein-cell formation. Conversely, overexpression of RSK dramatically suppressed the ERK-dependent differentiation, which was further augmented by mutations in the Ras/ERK pathway. Consistent with these physiological phenotypes, RSK negatively regulated ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK in a kinase activity-independent manner. In addition, we further demonstrated that the RSK-dependent inhibition of ERK nuclear migration is mediated by the physical association between ERK and RSK. Collectively, our study reveals a novel regulatory mechanism of the Ras/ERK pathway by RSK, which negatively regulates ERK activity by acting as a cytoplasmic anchor in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601180"xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Blenis J."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Koh H."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Sung J.H."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Chung C.J."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/author | "Jang C."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/pages | "3056-3067"xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/title | "Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development."xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16763554 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16763554 |
| http://purl.uniprot.org/citations/16763554 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16763554 |
| http://purl.uniprot.org/uniprot/P40417#attribution-731E8596696645B5853B9021E9772C48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16763554 |
| http://purl.uniprot.org/uniprot/P40417#attribution-D76FDC617EED47CA1C333A5F0E9B0685 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16763554 |
| http://purl.uniprot.org/uniprot/P11346#attribution-D76FDC617EED47CA1C333A5F0E9B0685 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16763554 |
| http://purl.uniprot.org/uniprot/P08646#attribution-D76FDC617EED47CA1C333A5F0E9B0685 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16763554 |
| http://purl.uniprot.org/uniprot/Q9VR61#attribution-622DB0D4ADF66807CDF99BF9B7E7E041 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16763554 |
| http://purl.uniprot.org/uniprot/Q9VR61#attribution-731E8596696645B5853B9021E9772C48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16763554 |