| http://purl.uniprot.org/citations/16765915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16765915 | http://www.w3.org/2000/01/rdf-schema#comment | "Fyn is a Src-family tyrosine kinase involved in neuronal development, transmission, and plasticity in mammalian central nervous system. We have previously reported that Fyn binds to a cytoskeletal protein, beta-adducin, in a phosphorylation-dependent manner. In the present report, we show that Fyn phosphorylates beta-adducin at tyrosine 489 located in its C-terminal tail domain. Phosphorylation of beta-adducin at Y489 was required for its association with the Fyn-SH2 domain. An antibody specific to the phosphorylated form of beta-adducin was raised in rabbits and showed that Y489 of beta-adducin was phosphorylated in wild type, but not in Fyn(-/-) mice, suggesting that Y489 of beta-adducin is phosphorylated downstream of Fyn in vivo. After phosphorylation at Y489, beta-adducin was translocated to the cell periphery, and colocalized with Fyn. These results suggest that Fyn phosphorylates and binds to beta-adducin at Y489, resulting in translocation of beta-adducin to the Fyn-enriched regions in the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.05.167"xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/author | "Okumura A."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/author | "Nagai K."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/author | "Yagi T."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/author | "Okumura N."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/author | "Shima T."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/author | "Gotoh H."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/pages | "600-605"xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/title | "Fyn-induced phosphorylation of beta-adducin at tyrosine 489 and its role in their subcellular localization."xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://purl.uniprot.org/core/volume | "346"xsd:string |
| http://purl.uniprot.org/citations/16765915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16765915 |
| http://purl.uniprot.org/citations/16765915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16765915 |
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| http://purl.uniprot.org/uniprot/#_Q9QYB8-mappedCitation-16765915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16765915 |
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| http://purl.uniprot.org/uniprot/P35612 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16765915 |
| http://purl.uniprot.org/uniprot/P39688 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16765915 |