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http://purl.uniprot.org/citations/16767679http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16767679http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study the distribution, frequency and structure of variable number of tandem repeats (VNTR) in 3' region of apoB gene in Chinese population.

Methods

Genomic DNA was extracted from peripheral blood obtained under consent from randomly-chosen 522 individuals who came to the hospital for physical examination, and used to screen for polymorphisms of 3' VNTR of the apoB gene by employing polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), gradient polyacrylamide gel electrophoresis, cloning and sequencing.

Results

Sixteen types of alleles of apoB 3oVNTR were identified, among which heterozygotes were more than homozygotes. The biggest allele is HVE58, and the smallest one is HVE22. HVE34 had the highest frequency (40.4%), followed by HVE32 (34.7%). This showed significant difference from the allelic distribution of other populations (Caucasian and Swedish). Through sequencing of 60 alleles, a new isomer (Y-A=ATAATTAAATATTT) and four new types of alleles were found.

Conclusion

The Chinese population we studied had a higher frequency of small alleles and showed a difference in allelic structure and frequency distribution from European and American in this populations."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/author"Wu G."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/author"Xue H."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/author"Du G."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/author"Chen B.S."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/author"Zeng W.W."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/pages"335-338"xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/title"[Structure analysis of apolipoprotein B 3' variable number of tandem repeats]."xsd:string
http://purl.uniprot.org/citations/16767679http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/16767679http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16767679
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