| http://purl.uniprot.org/citations/16769089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16769089 | http://www.w3.org/2000/01/rdf-schema#comment | "Several mouse models with defects in genes encoding components of the nucleotide excision repair (NER) pathway have been developed. In NER two different sub-pathways are known, i.e. transcription-coupled repair (TC-NER) and global-genome repair (GG-NER). A defect in one particular NER protein can lead to a (partial) defect in GG-NER, TC-NER or both. GG-NER defects in mice predispose to cancer, both spontaneous as well as UV-induced. As such these models (Xpa, Xpc and Xpe) recapitulate the human xeroderma pigmentosum (XP) syndrome. Defects in TC-NER in humans are associated with Cockayne syndrome (CS), a disease not linked to tumor development. Mice with TC-NER defects (Csa and Csb) are - except for the skin - not susceptible to develop (carcinogen-induced) tumors. Some NER factors, i.e. XPB, XPD, XPF, XPG and ERCC1 have functions outside NER, like transcription initiation and inter-strand crosslink repair. Deficiencies in these processes in mice lead to very severe phenotypes, like trichothiodystrophy (TTD) or a combination of XP and CS. In most cases these animals have a (very) short life span, display segmental progeria, but do not develop tumors. Here we will overview the available NER-related mouse models and will discuss their phenotypes in terms of (chemical-induced) tissue-specific tumor development, mutagenesis and premature aging features."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mrfmmm.2005.12.018"xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/author | "van der Horst G.T."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/author | "van Steeg H."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/author | "de Waard H."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/author | "Wijnhoven S.W."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/author | "Hoogervorst E.M."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/name | "Mutat Res"xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/pages | "77-94"xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/title | "Tissue specific mutagenic and carcinogenic responses in NER defective mouse models."xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://purl.uniprot.org/core/volume | "614"xsd:string |
| http://purl.uniprot.org/citations/16769089 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16769089 |
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