| http://purl.uniprot.org/citations/16769728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16769728 | http://www.w3.org/2000/01/rdf-schema#comment | "Long-pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity. PTX3 comprises a pentraxin-like C-terminal domain involved in complement activation via C1q interaction and an N-terminal extension with unknown functions. PTX3 binds fibroblast growth factor-2 (FGF2), inhibiting its pro-angiogenic and pro-restenotic activity. Here, retroviral transduced endothelial cells (ECs) overexpressing the N-terminal fragment PTX3-(1-178) showed reduced mitogenic activity in response to FGF2. Accordingly, purified recombinant PTX3-(1-178) binds FGF2, prevents PTX3/FGF2 interaction, and inhibits FGF2 mitogenic activity in ECs. Also, the monoclonal antibody mAb-MNB4, which recognizes the PTX3-(87-99) epitope, prevents FGF2/PTX3 interaction and abolishes the FGF2 antagonist activity of PTX3. Consistently, the synthetic peptides PTX3-(82-110) and PTX3-(97-110) bind FGF2 and inhibit the interaction of FGF2 with PTX3 immobilized to a BIAcore sensor chip, FGF2-dependent EC proliferation, and angiogenesis in vivo. Thus, the data identify a FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region, pointing to a novel function for the N-terminal extension of PTX3 and underlining the complexity of the PTX3 molecule for modular humoral pattern recognition."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m601023200"xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Bracci L."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Mantovani A."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Bastone A."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Bottazzi B."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Bugatti A."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Presta M."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Rusnati M."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Inforzato A."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Vincenti S."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Camozzi M."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/author | "Mastroianni D."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/pages | "22605-22613"xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/title | "Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3."xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16769728 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16769728 |
| http://purl.uniprot.org/citations/16769728 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16769728 |
| http://purl.uniprot.org/uniprot/#_P48759-mappedCitation-16769728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769728 |
| http://purl.uniprot.org/uniprot/#_D9ZGF5-mappedCitation-16769728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769728 |
| http://purl.uniprot.org/uniprot/#_F1N3T9-mappedCitation-16769728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769728 |
| http://purl.uniprot.org/uniprot/#_P09038-mappedCitation-16769728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769728 |