| http://purl.uniprot.org/citations/1676981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1676981 | http://www.w3.org/2000/01/rdf-schema#comment | "Pim-1 is an oncogene activated in mouse T-cell lymphomas induced by Moloney and AKR mink cell focus (MCF) viruses. Pim-1 was previously mapped to chromosome 17 by somatic cell hybrids, and subsequently to the region between the hemoglobin alpha-chain pseudogene 4 (Hba-4ps) and the alpha-crystalline gene (Crya-1) by Southern blot analysis of DNA obtained from panels of recombinant inbred strains. We have now mapped Pim-1 more accurately in t-haplotypes by analysis of recombinant t-chromosomes. The recombinants were derived from Tts6tf/t12 parents backcrossed to + tf/ + tf, and scored for recombination between the loci of T and tf. For simplicity all t-complex lethal genes properly named tcl-tx are shortened to tx. The Pim-1 gene was localized 0.6 cM proximal to the tw12 lethal gene, thus placing the Pim-1 gene 5.2 cM distal to the H-2 region in t-haplotypes. Once mapped, the Pim-1 gene was used as a marker for further genetic analysis of t-haplotypes. tw12 is so close to tf that even with a large number of recombinants it was not possible to determine whether it is proximal or distal to tf. Southern blot analysis of DNA from T-tf recombinants with a separation of tw12 and tf indicated that tw12 is proximal to tf. The mapping of two allelic t-lethals, t0 and t6 with respect to tw12 and tf has also been a problem.(ABSTRACT TRUNCATED AT 250 WORDS)"xsd:string |
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| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/author | "Bennett D."xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/author | "Artzt K."xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/author | "Ark B."xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/author | "Gummere G."xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/pages | "385-389"xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/title | "Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted)."xsd:string |
| http://purl.uniprot.org/citations/1676981 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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