| http://purl.uniprot.org/citations/16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16769899 | http://www.w3.org/2000/01/rdf-schema#comment | "Membranoproliferative glomerulonephritis (MPGN) type II (dense deposit disease) is an inflammatory renal disease characterized by electron-dense deposits and complement C3 on the glomerular basement membrane. There is no effective therapy. We investigated the role of C5 activation in a model of MPGN that develops spontaneously in complement factor H-deficient mice (Cfh(-/-)). At 12 months there was a significant reduction in mortality, glomerular cellularity, neutrophil numbers, and serum creatinine levels in Cfh(-/-) mice deficient in C5. Excessive glomerular neutrophil numbers, frequently seen in patients with MPGN during disease flares, were also observed in Cfh(-/-) mice after the administration of an antiglomerular basement membrane antibody. This exaggerated injurious phenotype was absent in Cfh(-/-) mice deficient in C5 but not in Cfh(-/-) mice deficient in C6, indicating a key role for C5 activation in the induction of renal lesions. Importantly, the renal injury was completely reversed in Cfh(-/-) mice pretreated with an anti-murine C5 antibody. These results demonstrate an important role for C5 in both spontaneous MPGN and experimentally induced nephritis in factor H-deficient mice and provide preliminary evidence that C5 inhibition therapy might be useful in human MPGN type II."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0601094103"xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Warren J."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Pickering M.C."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Rose K.L."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Botto M."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Walport M.J."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Cook H.T."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/author | "Carlucci F."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/pages | "9649-9654"xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/title | "Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/16769899 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16769899 |
| http://purl.uniprot.org/citations/16769899 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16769899 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWP4-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVP8-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUU3-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |
| http://purl.uniprot.org/uniprot/#_E9Q8H9-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |
| http://purl.uniprot.org/uniprot/#_E9Q8I0-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |
| http://purl.uniprot.org/uniprot/#_D6RGQ0-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |
| http://purl.uniprot.org/uniprot/#_Q8BNV3-mappedCitation-16769899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16769899 |