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http://purl.uniprot.org/citations/16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16770077http://www.w3.org/2000/01/rdf-schema#comment"

Objective

SNP/phenotype associations are difficult to validate. This comparative study demonstrates significant contribution of candidate genes to the variation of a complex cholesterol phenotype, measured in two general populations by a gene-based approach.

Methods

Independent samples of normolipidemic subjects from two Caucasian populations (371 Swiss and 157 Germans) were selected for a case-control-study (high LDL/low HDL versus low LDL/high HDL) with SNP genotypes as independent factors. We examined locus-specific common SNPs that densely cover the genomic regions of 10 lipid genes.

Results

Genotype effects were concordant in both ethnic samples, showing that APOE, ABCA1, CETP, and to a lesser degree LDLR, LIPC, and PLTP explained a substantial part of the genetic variation, whereas LPL was associated in only one sample. APOA1, LCAT, and SRB1 exerted no measurable influence.

Conclusion

This comparison showed that sets of common SNPs representing candidate regions reproducibly validate significant linkage disequilibrium association with a complex metabolic trait."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.org/dc/terms/identifier"doi:10.1159/000093773"xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Costanza M.C."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Morabia A."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Nurnberg P."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Toliat M.R."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Luft F.C."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Knoblauch H."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Reich J.G."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Bauerfeind A."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/author"Luganskaja T."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/name"Hum Hered"xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/pages"123-131"xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/title"Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations."xsd:string
http://purl.uniprot.org/citations/16770077http://purl.uniprot.org/core/volume"61"xsd:string
http://purl.uniprot.org/citations/16770077http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16770077
http://purl.uniprot.org/citations/16770077http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16770077
http://purl.uniprot.org/uniprot/#_A0A0E3KII0-mappedCitation-16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16770077
http://purl.uniprot.org/uniprot/#_A0A0E3MS57-mappedCitation-16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16770077
http://purl.uniprot.org/uniprot/#_A0A024R3E3-mappedCitation-16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16770077
http://purl.uniprot.org/uniprot/#_A8K2M5-mappedCitation-16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16770077
http://purl.uniprot.org/uniprot/#_P11150-mappedCitation-16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16770077
http://purl.uniprot.org/uniprot/#_A0A0S2Z3B1-mappedCitation-16770077http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16770077
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