| http://purl.uniprot.org/citations/16770336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16770336 | http://www.w3.org/2000/01/rdf-schema#comment | "Cigarette smoking is a complex behavioral phenotype to which environmental, psychological and genetic factors contribute. The purpose of this study was to investigate these multifactorial effects with a specific focus on young women and on genes that encode serotonin (5-HT) receptors and the 5-HT transporter. A case-control sample of female Israeli college students provided comprehensive background data and details of cigarette smoking and completed a battery of psychological instruments. They were divided into smoking initiators (SI, n=242) or non-initiators (NI, n=148); SI were further subdivided into high (HND, n=127) and low nicotine-dependent smokers (LND, n=115) on the basis of their scores on the Fagerstrom Tolerance Questionnaire (FTQ). Single-nucleotide polymorphisms (SNPs) in five serotonin receptor genes (HTR1A, HTR1B, HTR2A, HTR2C and HTR6) and the 5-HT transporter-linked polymorphic region (5-HTTLPR) were genotyped. In a logistic regression model for SI (chi2=117.90, P=1.6 x 10(-19), Nagelkerke R2=0.42), novelty seeking (odds ratio (OR)=1.134, P=0.00009) was a significant risk factor. A five SNP CACCC haplotype in HTR6 was a strong protective factor against SI (OR=0.26; P=0.007). The interaction of HTR6-C276T genotype and lifetime traumatic experience contributed strongly to the risk of SI (OR=13.88, P=0.0001). Specifically, subjects homozygous for the HTR6-C276T C allele showed significantly increased risk of SI if they had experienced trauma. Although significant (chi2=42.85, P=1.00 x 10(-7)), the best-fitting model for ND was less predictive than the model for SI (Nagelkerke R2=0.24). HTR1B-G861C GG genotype (OR=2.29, P=0.01) was a significant risk factor for HND. Further studies should consider the interactive contribution of life events and relevant gene variants to cigarette smoking and other complex behavioral traits."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.mp.4001855"xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/author | "Ebstein R.P."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/author | "Lerer B."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/author | "Kanyas K."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/author | "Karni O."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/author | "Lerer E."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/pages | "771-781"xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/title | "Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes."xsd:string |
| http://purl.uniprot.org/citations/16770336 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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