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| http://purl.uniprot.org/citations/16772167 | http://www.w3.org/2000/01/rdf-schema#comment | "LIM transcription factors confer developing axons with specific navigational properties, but the downstream guidance receptors and ligands are not well defined. The dermomyotome, a transient structure from which axial muscles arise, is the source of a secreted long-range chemoattractant specific for medial-class spinal motor neuron axons (MMCm axons). We show that fibroblast growth factors (FGFs) produced by the dermomyotome selectively attract MMCm axons in vitro. FGF receptor 1 (FGFR1) expression is restricted to MMCm neurons, and conditional deletion of FGFR1 causes motor axon guidance defects. Furthermore, reprogramming the identity of limb-innervating motor neurons to that of dermomyotome-innervating MMCm cells using the LIM factor Lhx3 induces FGFR1 expression and shifts an increased number of motor axons to an FGF-responsive state. These results point to a role for FGF signaling in axon guidance and further unravel how downstream effectors of LIM codes direct wiring of the developing nervous system."xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.04.030"xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/author | "Shirasaki R."xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/author | "Lewcock J.W."xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/author | "Pfaff S.L."xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/author | "Lettieri K."xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/pages | "841-853"xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/title | "FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code."xsd:string |
| http://purl.uniprot.org/citations/16772167 | http://purl.uniprot.org/core/volume | "50"xsd:string |
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