| http://purl.uniprot.org/citations/16772326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16772326 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulation of intracellular lipid may contribute to defective insulin secretion in type 2 diabetes. Although Zucker diabetic fatty (ZDF; fa/fa) rat islets are fat-laden and overexpress the lipogenic master gene, sterol regulatory element binding protein 1c (SREBP-1c), the contribution of SREBP-1c to the secretory defects observed in this model remains unclear. Here we compare the gene expression profile of lean control (fa/+) and ZDF rat islets in the absence or presence of dominant-negative SREBP-1c (SREBP-1c DN). ZDF islets displayed elevated basal insulin secretion at 3 mmol/l glucose but a severely depressed response to 17 mmol/l glucose. While SREBP-1c DN reduced basal insulin secretion from ZDF islets, glucose-stimulated insulin secretion was not improved. Of 57 genes differentially regulated in ZDF islets and implicated in glucose metabolism, vesicle trafficking, ion fluxes, and/or exocytosis, 21 were upregulated and 5 were suppressed by SREBP-1c DN. Genes underrepresented in ZDF islets were either unaffected (Glut-2, Kir6.2, Rab3), stimulated (voltage-dependent Ca(2+) channel subunit alpha1D, CPT2, SUR2, rab9, syt13), or inhibited (syntaxin 7, secretogranin-2) by SREBP-1c inhibition. Correspondingly, SREBP-1c DN largely corrected decreases in the expression of the transcription factors Pdx-1 and MafA but did not affect the abnormalities in Pax6, Arx, hepatic nuclear factor-1alpha (HNF1alpha), HNF3beta/Forkhead box-a2 (Foxa2), inducible cyclic AMP early repressor (ICER), or transcription factor 7-like 2 (TCF7L2) expression observed in ZDF islets. We conclude that upregulation of SREBP-1c and mild increases in triglyceride content do not explain defective glucose-stimulated insulin secretion from ZDF rats. However, overexpression of SREBP-1c may contribute to enhanced basal insulin secretion in this model."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00067.2006"xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Rutter G.A."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Briscoe C.P."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Parton L.E."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Sharpe E."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "McMillen P.J."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Diraison F."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/author | "Docherty E."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/pages | "E982-94"xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/title | "Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis."xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/16772326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16772326 |
| http://purl.uniprot.org/citations/16772326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16772326 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JZZ1-mappedCitation-16772326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16772326 |
| http://purl.uniprot.org/uniprot/#_P56720-mappedCitation-16772326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16772326 |
| http://purl.uniprot.org/uniprot/#_A6YP92-mappedCitation-16772326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16772326 |
| http://purl.uniprot.org/uniprot/#_A6HF27-mappedCitation-16772326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16772326 |
| http://purl.uniprot.org/uniprot/#_A6HF28-mappedCitation-16772326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16772326 |
| http://purl.uniprot.org/uniprot/A6YP92 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16772326 |
| http://purl.uniprot.org/uniprot/A0A0G2JZZ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16772326 |