| http://purl.uniprot.org/citations/1677358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1677358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1677358 | http://www.w3.org/2000/01/rdf-schema#comment | "Human apolipoprotein (apo) A-IV is a genetically polymorphic glyco-protein of 376 residues. We have recently reported the molecular basis for the two most common isoproteins, apoA-IV-1 and apoA-IV-2(Gln360----His), and for two rare variants, apoA-IV-0 (4-amino acid insertion) and apoA-IV-3(Glu230----Lys). In this report, we present the genetic basis for three additional isoproteins of apoA-IV. Sequence analysis of the apoA-IV-1 allele revealed a common nucleotide substitution which converts threonine (ACT), residue 347 of the mature protein, into serine (TCT). In one out of the five subjects with the apoA-IV-1/0 phenotype we identified two point mutations: 1) replacing the positively charged lysine (AAG), amino acid 167, with a negatively charged glutamic acid (GAG), and 2) converting the neutral residue 360, glutamine (CAG), to a positively charged histidine (CAT). We have also characterized four additional heterozygotes for the apoA-IV-3 allele. One individual was found to have the previously described substitution of lysine for glutamic acid at amino acid 230. The three other subjects had the identical mutation but at a different position in the polypeptide chain, residue 165. These results indicate that one predominant allele codes for the isoproteins apoA-IV-2 and apoA-IV-0 and that at least two major allelic variants for the isoproteins apoA-IV-1 and apoA-IV-3 are present in the population analyzed."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)92728-6"xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)92728-6"xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Lohse P."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Lohse P."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Brewer H.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Brewer H.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Rader D.J."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Rader D.J."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Kindt M.R."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/author | "Kindt M.R."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/pages | "13513-13518"xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/pages | "13513-13518"xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/title | "Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/title | "Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/1677358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1677358 |
| http://purl.uniprot.org/citations/1677358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1677358 |