| http://purl.uniprot.org/citations/16774925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16774925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16774925 | http://www.w3.org/2000/01/rdf-schema#comment | "SMOC-2 is a novel member of the SPARC family of matricellular proteins. The purpose of this study was to determine whether SMOC-2 can modulate angiogenic growth factor activity and angiogenesis. SMOC-2 was localized in the extracellular periphery of cultured human umbilical vein endothelial cells (HUVECs). Ectopically expressed SMOC-2 was also secreted into the tissue culture medium. In microarray profiling experiments, a recombinant SMOC-2 adenovirus induced the expression of transcripts required for cell cycle progression in HUVECs. Consistent with a growth-stimulatory role for SMOC-2, its overexpression stimulated DNA synthesis in a dose-dependent manner. Overexpressed SMOC-2 also synergized with vascular endothelial growth factor or with basic fibroblast growth factor to stimulate DNA synthesis. Ectopically expressed SMOC-2 stimulated formation of network-like structures as determined by in vitro matrigel angiogenesis assays. Fetal calf serum enhanced the stimulatory effect of overexpressed SMOC-2 in this assay. Conversely, small interference RNA directed toward SMOC-2 inhibited network formation and proliferation. The angiogenic activity of SMOC-2 was also examined in experimental mice by subdermal implantation of Matrigel plugs containing SMOC-2 adenovirus. SMOC-2 adenovirus induced a 3-fold increase in the number of cells invading Matrigel plugs when compared with a control adenoviral vector. Basic fibroblast growth factor and SMOC-2 elicited a synergistic effect on cell invasion. Taken together, our results demonstrate that SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m513463200"xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m513463200"xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Walsh K."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Walsh K."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Rocnik E.F."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Rocnik E.F."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Vaziri C."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/author | "Vaziri C."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/pages | "22855-22864"xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/pages | "22855-22864"xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/title | "The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/title | "The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity."xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16774925 | http://purl.uniprot.org/core/volume | "281"xsd:string |