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| http://purl.uniprot.org/citations/16777101 | http://www.w3.org/2000/01/rdf-schema#comment | "G6P translocase (G6PT) is thought to play a crucial role in transducing intracellular signaling events in brain tumor-derived cancer cells. In this report, we investigated the contribution of G6PT to the control of U-87 brain tumor-derived glioma cell survival using small interfering RNA (siRNA)-mediated suppression of G6PT. Three siRNA constructs were generated and found to suppress up to 91% G6PT gene expression. Flow cytometry analysis of propidium iodide/annexin-V-stained cells indicated that silencing the G6PT gene induced necrosis and late apoptosis. The anticancer agent curcumin, also inhibited G6PT gene expression by more than 90% and triggered U-87 glioma cells death. Overexpression of recombinant G6PT rescued the cells from curcumin-induced cell death. Targeting G6PT expression may provide a new mechanistic rationale for the action of chemopreventive drugs and lead to the development of new anti-cancer strategies."xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.05.071"xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/author | "Annabi B."xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/author | "Massillon D."xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/author | "Copland I.B."xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/author | "Belkaid A."xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/pages | "3746-3752"xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/title | "Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin."xsd:string |
| http://purl.uniprot.org/citations/16777101 | http://purl.uniprot.org/core/volume | "580"xsd:string |
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