| http://purl.uniprot.org/citations/16777605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16777605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16777605 | http://www.w3.org/2000/01/rdf-schema#comment | "The longevity of Caenorhabditis elegans is promoted by extra copies of the sir-2.1 gene in a manner dependent on the forkhead transcription factor DAF-16. We identify two C. elegans 14-3-3 proteins as SIR-2.1 binding partners and show that 14-3-3 genes are required for the life-span extension conferred by extra copies of sir-2.1. 14-3-3 proteins are also required for SIR-2.1-induced transcriptional activation of DAF-16 and stress resistance. Following heat stress, SIR-2.1 can bind DAF-16 in a 14-3-3-dependent manner. By contrast, low insulin-like signaling does not promote SIR-2.1/DAF-16 interaction, and sir-2.1 and the 14-3-3 genes are not required for the regulation of life span by the insulin-like signaling pathway. We propose the existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 act in parallel to the insulin-like pathway to activate DAF-16 and extend life span."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.04.036"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.04.036"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Berdichevsky A."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Berdichevsky A."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Guarente L."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Guarente L."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Viswanathan M."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/author | "Viswanathan M."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/pages | "1165-1177"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/pages | "1165-1177"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/title | "C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/title | "C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span."xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16777605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16777605 |
| http://purl.uniprot.org/citations/16777605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16777605 |