| http://purl.uniprot.org/citations/16777607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16777607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16777607 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription regulatory networks consist of physical and functional interactions between transcription factors (TFs) and their target genes. The systematic mapping of TF-target gene interactions has been pioneered in unicellular systems, using "TF-centered" methods (e.g., chromatin immunoprecipitation). However, metazoan systems are less amenable to such methods. Here, we used "gene-centered" high-throughput yeast one-hybrid (Y1H) assays to identify 283 interactions between 72 C. elegans digestive tract gene promoters and 117 proteins. The resulting protein-DNA interaction (PDI) network is highly connected and enriched for TFs that are expressed in the digestive tract. We provide functional annotations for approximately 10% of all worm TFs, many of which were previously uncharacterized, and find ten novel putative TFs, illustrating the power of a gene-centered approach. We provide additional in vivo evidence for multiple PDIs and illustrate how the PDI network provides insights into metazoan differential gene expression at a systems level."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.04.038"xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.04.038"xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Doucette-Stamm L."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Doucette-Stamm L."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Mukhopadhyay A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Mukhopadhyay A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Tissenbaum H.A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Tissenbaum H.A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Hope I.A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Hope I.A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Martinez N.J."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Martinez N.J."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Mango S.E."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Mango S.E."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Grove C.A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Grove C.A."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Reece-Hoyes J.S."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Reece-Hoyes J.S."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Walhout A.J."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Walhout A.J."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Sequerra R."xsd:string |
| http://purl.uniprot.org/citations/16777607 | http://purl.uniprot.org/core/author | "Sequerra R."xsd:string |