| http://purl.uniprot.org/citations/16777965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16777965 | http://www.w3.org/2000/01/rdf-schema#comment | "The circadian clock is driven by cell-autonomous transcription/translation feedback loops. The BMAL1 transcription factor is an indispensable component of the positive arm of this molecular oscillator in mammals. Here, we present a molecular genetic screening assay for mutant circadian clock proteins that is based on real-time circadian rhythm monitoring in cultured fibroblasts. By using this assay, we identified a domain in the extreme C terminus of BMAL1 that plays an essential role in the rhythmic control of E-box-mediated circadian transcription. Remarkably, the last 43 aa of BMAL1 are required for transcriptional activation, as well as for association with the circadian transcriptional repressor CRYPTOCHROME 1 (CRY1), depending on the coexistence of CLOCK protein. C-terminally truncated BMAL1 mutant proteins still associate with mPER2 (another protein of the negative feedback loop), suggesting that an additional repression mechanism may converge on the N terminus. Taken together, these results suggest that the C-terminal region of BMAL1 is involved in determining the balance between circadian transcriptional activation and suppression."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0601416103"xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Ueda H.R."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Yasuda M."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Yagita K."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Sugisawa Y."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Morita A."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Yamanaka I."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Tamanini F."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "van der Horst G.T."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Kiyohara Y.B."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/author | "Tagao S."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/pages | "10074-10079"xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/title | "The BMAL1 C terminus regulates the circadian transcription feedback loop."xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/16777965 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16777965 |
| http://purl.uniprot.org/citations/16777965 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16777965 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU61-mappedCitation-16777965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16777965 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUT8-mappedCitation-16777965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16777965 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS77-mappedCitation-16777965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16777965 |
| http://purl.uniprot.org/uniprot/#_O00327-mappedCitation-16777965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16777965 |