| http://purl.uniprot.org/citations/16778132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16778132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16778132 | http://www.w3.org/2000/01/rdf-schema#comment | "The natriuretic peptides are considered to be cardioprotective; however, their receptors have not been identified in human myocardium using radiolabeled analogs. Dendroaspis natriuretic peptide (DNP) has been recently identified as a new member of this peptide family and is thought to be less susceptible to enzymatic degradation. Therefore, we have developed the novel radiolabeled analog [125I]-DNP and used this to localize high-affinity (K(D)=0.2 nmol/L), saturable, specific binding sites in adult human heart (n=6) and coronary artery (n=8). In competition binding experiments, atrial natriuretic peptide and brain type natriuretic peptide had greater affinity for [125I]-DNP binding sites than C-type natriuretic peptide and the natriuretic peptide receptor (NPR)-C ligand, cANF. This rank order of potency suggested binding of [125I]-DNP was specific to NPR-A. Messenger RNA encoding NPR-A was identified in left ventricle and coronary artery smooth muscle, and expression was confirmed by immunocytochemical studies at the protein level. In addition, fluorescence dual labeling immunocytochemistry localized NPR-A protein to cardiomyocytes, endocardial endothelial cells, and smooth muscle of intramyocardial vessels. Importantly, we demonstrated a significant downregulation in the density of NPR-A in heart and coronary artery of patients with ischemic heart disease that may explain, in part, the attenuated natriuretic peptide response reported in this patient group."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000232322.06633.d3"xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000232322.06633.d3"xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Singh G."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Singh G."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Davenport A.P."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Davenport A.P."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Kuc R.E."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Kuc R.E."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Maguire J.J."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Maguire J.J."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Fidock M."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/author | "Fidock M."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/name | "Circ. Res."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/name | "Circ. Res."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/pages | "183-190"xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/pages | "183-190"xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/title | "Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/title | "Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure."xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/16778132 | http://purl.uniprot.org/core/volume | "99"xsd:string |