| http://purl.uniprot.org/citations/16780893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16780893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16780893 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-9 plays a key role in the intrinsic apoptotic pathway and currently two splice variants (caspase-9-alpha and -beta) have been identified. The present study cloned and characterized a novel caspase-9 splice variant, hereby designated Casp9-gamma. Casp9-gamma is generated from an additional alternative 3' splice site in the fourth exon of caspase-9, resulting in a 58-nucleotide fragment insertion compared with the full-length caspase-9-alpha. The fragment introduces an in-frame stop codon, and the resulting open reading frame (ORF) is preterminated. The Casp9-gamma comprises the deduced 154 amino acid residues containing only the caspase recruitment domain (CARD) and does not contain the large and small subunits. The Casp9-gamma does not promote apoptosis when overexpressed in mammalian cells. Moreover, it inhibits the cleavage of procaspase-3 mediated by proapoptotic member Bax or apoptosis inductor staurosporine. Therefore, Casp9-gamma may function as an endogenous apoptotic inhibitor by interfering with the CARD-CARD interaction between Apaf-1 (apoptotic protease activating factor-1) and procaspase-9. In addition, Casp9-gamma does not enhance NF-kappaB activation in transfected 293T cells, conflicting with previous evidence that the isolated CARD of caspase-9 activates NF-kappaB in ND7 cells. This suggests that the procaspase-9-mediated NF-kappaB activation in response to cellular stresses is cell type-specific through an unidentified mechanism."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lfs.2006.04.026"xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lfs.2006.04.026"xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/name | "Life Sci."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/name | "Life Sci."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/pages | "934-940"xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/pages | "934-940"xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/title | "Cloning of a novel human caspase-9 splice variant containing only the CARD domain."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/title | "Cloning of a novel human caspase-9 splice variant containing only the CARD domain."xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16780893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16780893 |
| http://purl.uniprot.org/citations/16780893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16780893 |
| http://purl.uniprot.org/citations/16780893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16780893 |
| http://purl.uniprot.org/citations/16780893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16780893 |