| http://purl.uniprot.org/citations/16781000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16781000 | http://www.w3.org/2000/01/rdf-schema#comment | "Background/aimsInterleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity.MethodsExpression of IL-15 and its receptors was evaluated in several liver injury models, primary hepatocytes, and two liver cell lines. Effects of IL-15 on viability, proliferation, and apoptosis were assessed in cultured liver cells, and also in the livers of healthy mice.ResultsIL-15 and its receptors are expressed constitutively in healthy livers, and ligand expression is induced in injured livers. Cultured primary hepatocytes and liver cell lines express IL-15 and its receptors. Administration of IL-15 has minimal effects on cultured liver cells, but significantly up-regulates oval cell accumulation, cyclin mRNA expression, and mature hepatocyte replication in healthy mice. These effects are associated with focal hepatic inflammation and increased expression of TNF-alpha and IFN-gamma, but not with increased cell death or aminotransferase release.ConclusionsIL-15 expression increases during liver injury and IL-15 treatment induces a wound healing-type response in healthy adult mice. These findings suggest that IL-15 may contribute to regenerative activity in damaged liver."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jhep.2006.04.008"xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Choi S.S."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Li Y.X."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "McCall S."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Diehl A.M."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Zdanowicz M."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Camp T."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/author | "Sicklick J.K."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/name | "J Hepatol"xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/pages | "410-418"xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/title | "Interleukin-15 increases hepatic regenerative activity."xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/16781000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16781000 |
| http://purl.uniprot.org/citations/16781000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16781000 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-16781000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16781000 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ7-mappedCitation-16781000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16781000 |
| http://purl.uniprot.org/uniprot/#_P48346-mappedCitation-16781000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16781000 |
| http://purl.uniprot.org/uniprot/#_Q3U1Z6-mappedCitation-16781000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16781000 |
| http://purl.uniprot.org/uniprot/#_Q9Z0G5-mappedCitation-16781000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16781000 |