| http://purl.uniprot.org/citations/16783819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16783819 | http://www.w3.org/2000/01/rdf-schema#comment | "Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in endothelial cells, epithelial cells, platelets, and some leukocytes. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. JAM-A also regulates cell motility, even though the quantitative biophysical features have not been characterized. In this study, we evaluated the role of JAM-A in the regulation of cell motility using JAM-A-expressing and JAM-A-deficient murine endothelial cells. We report that, in the absence of shear stress, JAM-A absence increases cell motility by increasing directional persistence but not cell speed. In addition, in the presence of shear stress, JAM-A absence increases protrusion extension in the direction of flow and increased downstream cellular displacement (while, conversely, decreasing upstream displacement). All these effects of JAM-A absence are mitigated by the microtubule-stabilizing compound taxol. A motility- and microtubule-related function, integrin-mediated adhesiveness, was only slightly reduced in JAM-A-deficient cells compared with JAM-A-expressing cells. However, overexpression of JAM-A in the JAM-A-deficient cells increased integrin adhesiveness to the same levels as those observed in taxol-treated JAM-A-deficient cells. Taken together, these data indicate that JAM-A regulates cell motility by cooperating with microtubule-stabilizing pathways."xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.20712"xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/author | "Cruz F."xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/author | "Bazzoni G."xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/pages | "122-130"xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/title | "Junctional adhesion molecule-A regulates cell migration and resistance to shear stress."xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/16783819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16783819 |
| http://purl.uniprot.org/citations/16783819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16783819 |
| http://purl.uniprot.org/uniprot/#_O88792-mappedCitation-16783819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16783819 |
| http://purl.uniprot.org/uniprot/#_Q9Y624-mappedCitation-16783819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16783819 |
| http://purl.uniprot.org/uniprot/Q9Y624 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16783819 |
| http://purl.uniprot.org/uniprot/O88792 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16783819 |