| http://purl.uniprot.org/citations/16787403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16787403 | http://www.w3.org/2000/01/rdf-schema#comment | "Calsenilin/potassium channel-interacting protein (KChIP)3/ downstream regulatory element sequence antagonist modulator (DREAM) is a neuronal calcium-binding protein that has been shown to have multiple functions in the cell, including the regulation of presenilin processing, repression of transcription and modulation of A-type potassium channels. To gain a better understanding of the precise role of calsenilin in specific cellular compartments, an interactor hunt for proteins that bind to the N-terminal domain of calsenilin was carried out. Using a yeast two-hybrid system and co-immunoprecipitation studies, we have identified the transcriptional co-repressor C-terminal binding protein (CtBP)2 as an interactor for calsenilin and have shown that the two proteins can interact in vivo. In co-immunoprecipitation studies, calsenilin also interacted with CtBP1, a CtBP2 homolog. Our data also showed a calsenilin-dependent increase in c-fos protein levels in CtBP knockout fibroblasts, suggesting that CtBP may modulate the transcriptional repression of c-fos by calsenilin. Furthermore, the finding that histone deacetylase protein and activity were associated with the calsenilin-CtBP immunocomplex suggests a mechanism by which calsenilin-CtBP may act to repress transcription. Finally, we demonstrated that calsenilin and CtBP are present in synaptic vesicles and can interact in vivo."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2006.03972.x"xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/author | "Buxbaum J.D."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/author | "Kajiwara Y."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/author | "Wasco W."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/author | "Zaidi N.F."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/author | "Kuplast K.G."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/author | "Washicosky K.J."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/pages | "1290-1301"xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/title | "Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s)."xsd:string |
| http://purl.uniprot.org/citations/16787403 | http://purl.uniprot.org/core/volume | "98"xsd:string |
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