| http://purl.uniprot.org/citations/16792528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16792528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16792528 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Fes protein tyrosine kinase is implicated in the differentiation of a number of cell types including neuronal, endothelial and myeloid cells. Structurally, Fes consists of a unique N-terminal region, followed by SH2 (Src homology domain 2) and kinase domains. Two coiled-coil (CC) domains (CC1 and CC2) located within the unique N-terminal region are critical regulators of Fes activity in vivo and may function to recruit Fes activators and/or substrates. A yeast two-hybrid screen, utilizing a K-562 cell cDNA library and the Fes CC2 domain as bait, identified an interacting clone encoding the CC domain and B-box motifs (residues 114-357) of the transcriptional co-repressor KRAB-associated protein (KAP)-1. KAP-1(114-357) interacted with full-length Fes in yeast, and the KAP-1 CC domain was sufficient to bind the Fes N-terminal region in Sf-9 cells. Co-expression of Fes with full-length KAP-1 in human 293T cells stimulated Fes autophosphorylation and led to KAP-1 tyrosine phosphorylation. Association of endogenous Fes and KAP-1 was also observed in HL-60 myeloid leukaemia cells. Together, these data identify a novel Fes-KAP-1 interaction, and suggest a dual role for KAP-1 as both a Fes activator and downstream effector."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20060194"xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20060194"xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/author | "Shaffer J.M."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/author | "Shaffer J.M."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/author | "Smithgall T.E."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/author | "Smithgall T.E."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/author | "Delfino F.J."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/author | "Delfino F.J."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/pages | "141-150"xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/pages | "141-150"xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/title | "The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/title | "The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/volume | "399"xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://purl.uniprot.org/core/volume | "399"xsd:string |
| http://purl.uniprot.org/citations/16792528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16792528 |
| http://purl.uniprot.org/citations/16792528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16792528 |
| http://purl.uniprot.org/citations/16792528 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16792528 |
| http://purl.uniprot.org/citations/16792528 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16792528 |