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http://purl.uniprot.org/citations/16792864http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16792864http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study the relationship between a G/T substitution at position -88 of myxovirus resistance-1 gene (MxA) and the self-limiting or chronic infection of HBV.

Methods

Blood samples from 100 patients with self-limiting HBV infection (positive anti-HBs and anti-HBc) and from 340 patients with chronic HBV infection were collected. MxA-88 G/T polymorphism was typed using a protocol based on competitively differentiated-polymerase chain reaction. For statistical analysis, odds ratio and chi-square test were used.

Results

The detective rate of G/G genotype (low expression genotype) of MxA-88 G/T was 50.2% (221/440), those of T/T genotype (high expression genotype) and G/T heterozygous genotype were 5.5% (24/440) and 44.3% (195/440). Compared to patients with chronic infection, patients with self-limiting infection had lower frequency of G/G genotype (41.0% vs 52.9%, P < 0.05) or G allele (62.5% vs 75.9%, P < 0.01) and had higher frequency of T/T genotype (16.0% vs 2.4%, P < 0.01) or T allele (37.5% vs 24.1%, P < 0.01), but there was no significant difference in the G/T heterozygous genotype.

Conclusions

MxA gene -88 G/T polymorphism influences the natural outcomes of HBV infection to some extent. This SNP of MxA gene may be used as a clinical prognostic marker of HBV infection."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/author"Gu L."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/author"Huang Y.S."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/author"Gao Z.L."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/author"Peng X.M."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/author"Yin S.C."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/name"Zhonghua Gan Zang Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/pages"418-421"xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/title"[MxA gene-88 G/T polymorphism influences the outcomes of HBV infection]."xsd:string
http://purl.uniprot.org/citations/16792864http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/16792864http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16792864
http://purl.uniprot.org/citations/16792864http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16792864
http://purl.uniprot.org/uniprot/#_H9KVC7-mappedCitation-16792864http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16792864
http://purl.uniprot.org/uniprot/#_P20591-mappedCitation-16792864http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16792864
http://purl.uniprot.org/uniprot/#_Q8NAA8-mappedCitation-16792864http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16792864
http://purl.uniprot.org/uniprot/P20591http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16792864
http://purl.uniprot.org/uniprot/H9KVC7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16792864
http://purl.uniprot.org/uniprot/Q8NAA8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16792864