DESCRIBE <http://purl.uniprot.org/citations/16796407>

Subject	Predicate	Object
http://purl.uniprot.org/citations/16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16796407	http://www.w3.org/2000/01/rdf-schema#comment	" Background The physiopathology of the brain ischemia includes many events such as important apoptotic mechanisms were Fas protein is expressed. Statins have neuroprotector effects that are independent of their blood lipid reducing actions. Objective Study of the atorvastatin effect on Fas expression in brain ischemia. Material and methods Fifteen male Sprague Dawley rats were distributed in three groups (n=5), the control group without cerebral ischemia, in the other two experimental groups (1 and 2) a global cerebral ischemia were induced by respiratory arrest (D-tubocurarin). Experimental group 2 was treated with atorvastatin (10 mg/Kg/d, p.o.) during two weeks before the induction of the ischemia. Immunohistochemical study of brain frontal specimens was done by the Avidin-Biotin-Peroxidase method. Results Fas was expressed in 38% of cells in non ischemic brain, this expression increased to 63% of cells in ischemic brain samples (P = 0.0003) Fas expression in ischemia was significantly inhibited by atorvastatin in 23% (P = 0.0007). Conclusions Atorvastatin decreased Fas expression in ischemic brain. This fact must be taken into account to explain the atorvastatin neuroprotection and suggests the potential use such as primary prevention for ischemic attacks."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.org/dc/terms/identifier	"doi:10.4321/s0212-71992006000400003"xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/author	"Corado Ramirez J."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/author	"Eblen-Zajjurz A."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/author	"Oria de Suarez C."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/author	"Ponce Hernandez L."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/author	"Suarez Rodriguez S."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/author	"Tovar Mendoza R."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/date	"2006"xsd:gYear
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/name	"An Med Interna"xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/pages	"156-160"xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/title	"[Effect of atorvastatin on Fas (CD95/Apo-1) expression in normal or ischemic brain]."xsd:string
http://purl.uniprot.org/citations/16796407	http://purl.uniprot.org/core/volume	"23"xsd:string
http://purl.uniprot.org/citations/16796407	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/16796407
http://purl.uniprot.org/citations/16796407	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/16796407
http://purl.uniprot.org/uniprot/#_A0A8I6ALF0-mappedCitation-16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/#_A0A8I6G9W1-mappedCitation-16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/#_A0A8I5ZN15-mappedCitation-16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/#_A0A8I6AC34-mappedCitation-16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/#_F1LWQ2-mappedCitation-16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/#_Q63199-mappedCitation-16796407	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/A0A8I6G9W1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/Q63199	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16796407
http://purl.uniprot.org/uniprot/A0A8I6ALF0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16796407