| http://purl.uniprot.org/citations/16802330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16802330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16802330 | http://www.w3.org/2000/01/rdf-schema#comment | "Molecules involved in axon guidance have recently also been shown to play a role in blood vessel guidance. To examine whether axon guidance molecules, such as the EphA4 receptor tyrosine kinase, might also play a role in development of the central nervous system (CNS) vasculature and repair following CNS injury, we examined wild-type and EphA4 null mutant (-/-) mice. EphA4-/-mice exhibited an abnormal CNS vascular structure in both the cerebral cortex and the spinal cord, with disorganized branching and a 30% smaller diameter. During development, EphA4 was expressed on endothelial cells. This pattern of expression was not maintained in the adult. After spinal cord injury in wild-type mice, expression of EphA4 was markedly up-regulated on activated astrocytes, many of which were tightly associated with blood vessels. In EphA4-/-spinal cord following injury, astrocytes were not as tightly associated with blood vessels as the wild-type astrocytes. In uninjured EphA4-/-mice, the blood-brain barrier (BBB) appeared normal, but it showed prolonged leakage following spinal cord injury. These results support a role for EphA4 in CNS vascular formation and guidance during development and an additional role in BBB repair."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.21029"xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.21029"xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Bartlett P.F."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Bartlett P.F."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Galea M.P."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Galea M.P."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Goldshmit Y."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Goldshmit Y."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Turnley A.M."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/author | "Turnley A.M."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/name | "J. Comp. Neurol."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/name | "J. Comp. Neurol."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/pages | "864-875"xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/pages | "864-875"xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/title | "EphA4 regulates central nervous system vascular formation."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/title | "EphA4 regulates central nervous system vascular formation."xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/volume | "497"xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://purl.uniprot.org/core/volume | "497"xsd:string |
| http://purl.uniprot.org/citations/16802330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16802330 |
| http://purl.uniprot.org/citations/16802330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16802330 |