| http://purl.uniprot.org/citations/16807248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16807248 | http://www.w3.org/2000/01/rdf-schema#comment | "Survivin is a multifunctional member of the IAP (inhibitor of apoptosis) family, but its molecular interactions in protection from cell death and regulation of cell division have not been completely elucidated. In a proteomics screening to identify novel survivin-binding partners, we found that the aryl hydrocarbon receptor-interacting protein (AIP) directly associates with survivin in vitro and in co-immunoprecipitation experiments in vivo. This interaction is mediated by the carboxyl-terminal end of AIP, which contains three tetratricopeptide motifs, and involves the carboxyl terminus coiled coil in survivin with critical roles of Asp(142) in AIP recognition. A survivin mutant lacking only Asp(142) fails to bind AIP and exhibits accelerated degradation in vivo in a reaction reversed by a proteasome inhibitor. Acute knock-down of AIP by short interference RNA or competition of the survivin-AIP complex by peptidyl mimicry destabilizes survivin levels in cells, with enhanced apoptosis but no changes in cell cycle progression. Therefore, AIP regulates survivin stability, thus elevating a cellular anti-apoptotic threshold. The survivin-AIP complex may influence the cellular xenobiotic response to environmental toxin(s) and contribute to subcellular chaperone trafficking during cell death regulation."xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m603175200"xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/author | "Altieri D.C."xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/author | "Kang B.H."xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/pages | "24721-24727"xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/title | "Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein."xsd:string |
| http://purl.uniprot.org/citations/16807248 | http://purl.uniprot.org/core/volume | "281"xsd:string |
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