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http://purl.uniprot.org/citations/1680927http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1680927http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1680927http://www.w3.org/2000/01/rdf-schema#comment"NK cells lyse tumor cells and virally infected cells, but the molecular basis for this phenomenon has not been defined. A mAb specific for the rat cell surface molecule, NKR-P1, stimulates rat NK cell lytic activity and is reactive with all rat NK cells, suggesting that this molecule may play a significant role in NK cell function. We have previously described another NK cell-specific Ag, Ly-49, that belongs to a family of cross-hybridizing genes on distal mouse chromosome 6. The rat NKR-P1 Ag shares several features with the mouse Ly-49 Ag, including selective cell surface expression on NK cells, homology to the C-type lectins, expression as a type II integral membrane protein, and disulfide-linked homodimeric structure. To further examine the relationship of NKR-P1 to Ly-49, we have cloned the cDNA encoding a mouse homologue of NKR-P1 (mNKR-P1). The mouse and rat NKR-P1-deduced polypeptide sequences are highly conserved, suggesting a similar tertiary structure. By examination of DNA from informative recombinant inbred mice with Southern blot analysis, we have determined that mNKR-P1 is encoded by a distinct gene that is genetically linked to the Ly-49 locus, lying within 0.5 centi-Morgan (cM) of Ly-49. Although the deduced amino acid sequences of mNKR-P1 and Ly-49 reveal that these proteins are structurally similar, they are only 24% identical at the amino acid level and the cDNA sequences do not demonstrate significant nucleotide homology. Our studies suggest that we have identified a region on mouse chromosome 6 that includes distinct NK-specific genes that encode structurally related proteins (type II integral membrane proteins, C-type lectin super-gene family) but which demonstrate considerable heterogeneity. We have termed this genetic region the NK complex."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Stark M."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Stark M."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Yokoyama W.M."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Yokoyama W.M."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Ryan J.C."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Ryan J.C."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Seaman W.E."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Seaman W.E."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Hunter J.J."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Hunter J.J."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Smith H.R.C."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/author"Smith H.R.C."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/name"J. Immunol."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/name"J. Immunol."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/pages"3229-3236"xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/pages"3229-3236"xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/title"cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/title"cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6."xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/volume"147"xsd:string
http://purl.uniprot.org/citations/1680927http://purl.uniprot.org/core/volume"147"xsd:string
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