| http://purl.uniprot.org/citations/16809760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16809760 | http://www.w3.org/2000/01/rdf-schema#comment | "The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-gamma (PLC-gamma); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2(-/-) mice. 3BP2(-/-) mice had increased accumulation of pre-B cells in the bone marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2 stage, but normal numbers of mature B cells. B-cell proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to B-cell receptor (BCR) ligation were all impaired. These results suggest that 3BP2 is important for BCR, but not for TCR signaling."xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00087-06"xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/author | "Kumar L."xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/author | "de la Fuente M.A."xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/pages | "5214-5225"xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/title | "3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation."xsd:string |
| http://purl.uniprot.org/citations/16809760 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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