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http://purl.uniprot.org/citations/16815164http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16815164http://www.w3.org/2000/01/rdf-schema#comment"

Background

Resistin-like molecule (RELM) beta is a cysteine-rich cytokine expressed in the gastrointestinal tract and implicated in insulin resistance and gastrointestinal nematode immunity; however, its function primarily remains an enigma.

Objective

We sought to elucidate the function of RELM-beta in the gastrointestinal tract.

Methods

We generated RELM-beta gene-targeted mice and examined colonic epithelial barrier function, gene expression profiles, and susceptibility to acute colonic inflammation.

Results

We show that RELM-beta is constitutively expressed in the colon by goblet cells and enterocytes and has a role in homeostasis, as assessed by alterations in colon mRNA transcripts and epithelial barrier function in the absence of RELM-beta. Using acute colonic inflammatory models, we demonstrate that RELM-beta has a central role in the regulation of susceptibility to colonic inflammation. Mechanistic studies identify that RELM-beta regulates expression of type III regenerating gene (REG) (REG3beta and gamma), molecules known to influence nuclear factor kappaB signaling.

Conclusions

These data define a critical role for RELM-beta in the maintenance of colonic barrier function and gastrointestinal innate immunity.

Clinical implications

These findings identify RELM-beta as an important molecule in homeostatic gastrointestinal function and colonic inflammation, and as such, these results have implications for a variety of human inflammatory gastrointestinal conditions, including allergic gastroenteropathies."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.org/dc/terms/identifier"doi:10.1016/j.jaci.2006.04.039"xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Mishra A."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Murphy A.J."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Valenzuela D.M."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Yancopoulos G.D."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Artis D."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Rothenberg M.E."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Blanchard C."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Hogan S.P."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Karow M.L."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Ahrens R."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Groschwitz K."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/author"Seidu L."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/name"J Allergy Clin Immunol"xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/pages"257-268"xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/title"Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility."xsd:string
http://purl.uniprot.org/citations/16815164http://purl.uniprot.org/core/volume"118"xsd:string
http://purl.uniprot.org/citations/16815164http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16815164
http://purl.uniprot.org/citations/16815164http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16815164
http://purl.uniprot.org/uniprot/#_A0A0R4J042-mappedCitation-16815164http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16815164
http://purl.uniprot.org/uniprot/#_Q99P86-mappedCitation-16815164http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16815164
http://purl.uniprot.org/uniprot/#_Q8K425-mappedCitation-16815164http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16815164
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