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| http://purl.uniprot.org/citations/16815590 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrocyst formation in the cellular slime moulds is a sexual process induced under dark and humid conditions. Normal development life cycle in these organisms involves proliferation by cell division and, upon starvation, formation of multicellular aggregates and fruiting bodies, consisting of spores and stalk cells. Macrocyst formation, cell division by binary fission and spore formation are thus three alternative modes of reproduction, for which it is of interest to understand how a choice is made. The genetic basis of asexual development and fruiting body formation is well known, by contrast information on the genetic control of sexual reproduction during macrocyst formation is scarce. In Dictyostelium discoideum, the most widely used species, several cell-surface proteins relevant to sexual cell fusion have been identified using cell fusion-blocking antibodies, but isolation of the relevant genes has been unsuccessful. Analysis of sexually deficient mutants, some of which are normal for asexual development, has shown that sexual reproduction is regulated by both specific genes and genes that are also involved in asexual development. Reverse genetic analysis of 24 genes highly enriched in a gamete-specific subtraction library has revealed four genes involved in the regulation of sexual cell interactions. One of them was found to be a novel regulator of the cAMP signalling pathway specific to sexual development. Studies on the molecular genetic control of the sexual cycle will be reviewed and their contribution to our understanding of the organization and function of the D. discoideum genome as a whole discussed."xsd:string |
| http://purl.uniprot.org/citations/16815590 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejcb.2006.05.012"xsd:string |
| http://purl.uniprot.org/citations/16815590 | http://purl.uniprot.org/core/author | "Urushihara H."xsd:string |
| http://purl.uniprot.org/citations/16815590 | http://purl.uniprot.org/core/author | "Muramoto T."xsd:string |
| http://purl.uniprot.org/citations/16815590 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16815590 | http://purl.uniprot.org/core/name | "Eur J Cell Biol"xsd:string |
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| http://purl.uniprot.org/citations/16815590 | http://purl.uniprot.org/core/title | "Genes involved in Dictyostelium discoideum sexual reproduction."xsd:string |
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