| http://purl.uniprot.org/citations/16818237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16818237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16818237 | http://www.w3.org/2000/01/rdf-schema#comment | "Granzyme A (GzmA) activates a caspase-independent cell death pathway with morphological features of apoptosis. Single-stranded DNA damage is initiated when the endonuclease NM23-H1 becomes activated to nick DNA after granzyme A cleaves its inhibitor, SET. SET and NM23-H1 reside in an endoplasmic reticulum-associated complex (the SET complex) that translocates to the nucleus in response to superoxide generation by granzyme A. We now find the 3'-to-5' exonuclease TREX1, but not its close homolog TREX2, in the SET complex. TREX1 binds to SET and colocalizes and translocates with the SET complex. NM23-H1 and TREX1 work in concert to degrade DNA. Silencing NM23-H1 or TREX1 inhibits DNA damage and death of cells treated with perforin (PFN) and granzyme A, but not of cells treated with perforin and granzyme B (GzmB). After granzyme A activates NM23-H1 to make single-stranded nicks, TREX1 removes nucleotides from the nicked 3' end to reduce the possibility of repair by rejoining the nicked ends."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.06.005"xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.06.005"xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Chowdhury D."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Chowdhury D."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Demple B."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Demple B."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Beresford P.J."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Beresford P.J."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Lieberman J."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Lieberman J."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Perrino F.W."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Perrino F.W."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Sung J.S."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/author | "Sung J.S."xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16818237 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |