| http://purl.uniprot.org/citations/16818875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16818875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16818875 | http://www.w3.org/2000/01/rdf-schema#comment | "The neurotransmitter glutamate mediates excitatory synaptic transmission by activating ionotropic glutamate receptors (iGluRs). In Caenorhabditis elegans, the GLR-1 receptor subunit is required for glutamate-gated current in a subset of interneurons that control avoidance behaviors. Current mediated by GLR-1-containing iGluRs depends on SOL-1, a transmembrane CUB-domain protein that immunoprecipitates with GLR-1. We have found that reconstitution of glutamate-gated current in heterologous cells depends on three proteins, STG-1 (a C. elegans stargazin-like protein), SOL-1, and GLR-1. Here, we use genetic and pharmacological perturbations along with rapid perfusion electrophysiological techniques to demonstrate that SOL-1 functions to slow the rate and limit the extent of receptor desensitization as well as to enhance the recovery from desensitization. We have also identified a SOL-1 homologue from Drosophila and show that Dro SOL1 has a conserved function in promoting C. elegans glutamate-gated currents. SOL-1 homologues may play critical roles in regulating glutamatergic neurotransmission in more complex nervous systems."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0604520103"xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0604520103"xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Maricq A.V."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Maricq A.V."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Francis M.M."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Francis M.M."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Madsen D.M."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Madsen D.M."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Walker C.S."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Walker C.S."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Brockie P.J."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/author | "Brockie P.J."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/pages | "10787-10792"xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/pages | "10787-10792"xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/title | "Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization."xsd:string |
| http://purl.uniprot.org/citations/16818875 | http://purl.uniprot.org/core/title | "Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization."xsd:string |