| http://purl.uniprot.org/citations/16821125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16821125 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines are now known to play an important role in cancer growth and metastasis. Here we report that differentiating osteoclasts constitutively produce CCL22 (also called macrophage-derived chemokine) and potentially promote bone metastasis of lung cancer expressing its receptor CCR4. We first examined expression of chemokines by differentiating osteoclasts. CCL22 was selectively upregulated in osteoclast-like cells derived from RAW264.7 cells and mouse bone marrow cells upon stimulation with RANKL (receptor activator of nuclear factor-kappaB ligand). In addition, a human lung cancer cell line SBC-5 that efficiently metastasized to bone when intravenously injected into NK cell-depleted SCID mice was found to express CCR4. Stimulation of SBC-5 cells with CCL22 induced cell migration and also enhanced phosphorylation of protein kinase B/Akt and extracellular signal-regulated kinase (ERK). Furthermore, immunohistochemical analysis of bone metastasis lesions demonstrated close co-localization of tartrate-resistant alkaline phosphatase (TRAP)-positive osteoclasts expressing CCL22 and SBC-5 cells expressing CCR4. Collectively, these results suggest that osteoclasts may promote bone metastasis of cancer cells expressing CCR4 in the bone marrow by producing its ligand CCL22."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10585-006-9006-1"xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Nakayama T."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Saitoh Y."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Sakurai H."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Arita Y."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Yoshie O."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Saiki I."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/author | "Nakamura E.S."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/name | "Clin Exp Metastasis"xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/pages | "9-18"xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/title | "RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4."xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/16821125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16821125 |
| http://purl.uniprot.org/citations/16821125 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16821125 |
| http://purl.uniprot.org/uniprot/#_O88430-mappedCitation-16821125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16821125 |
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| http://purl.uniprot.org/uniprot/#_O35235-mappedCitation-16821125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16821125 |
| http://purl.uniprot.org/uniprot/#_Q059M3-mappedCitation-16821125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16821125 |
| http://purl.uniprot.org/uniprot/#_Q8WTX0-mappedCitation-16821125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16821125 |