| http://purl.uniprot.org/citations/16822840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16822840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16822840 | http://www.w3.org/2000/01/rdf-schema#comment | "The microphthalmia-associated transcription factor (MITF) is required for terminal osteoclast differentiation and is a target for signaling pathways engaged by colony stimulating factor (CSF)-1 and receptor-activator of nuclear factor-kappaB ligand (RANKL). Work presented here demonstrates that MITF can shuttle from cytoplasm to nucleus dependent upon RANKL/CSF-1 action. 14-3-3 was identified as a binding partner of MITF in osteoclast precursors, and overexpression of 14-3-3 in a transgenic model resulted in increased cytosolic localization of MITF and decreased expression of MITF target genes. MITF/14-3-3 interaction was phosphorylation dependent, and Ser173 residue, within the minimal interaction region of amino acid residues 141-191, was required. The Cdc25C-associated kinase (C-TAK)1 interacted with an overlapping region of MITF. C-TAK1 increased MITF/14-3-3 complex formation and thus promoted cytoplasmic localization of MITF. C-TAK1 interaction was disrupted by RANKL/CSF-1 treatment. The results indicate that 14-3-3 regulates MITF activity by promoting the cytosolic localization of MITF in the absence of signals required for osteoclast differentiation. This work identifies a mechanism that regulates MITF activity in monocytic precursors that are capable of undergoing different terminal differentiation programs, and it provides a mechanism that allows committed precursors to rapidly respond to signals in the bone microenvironment to promote specifically osteoclast differentiation."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-05-0470"xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-05-0470"xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Hu R."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Hu R."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Ostrowski M.C."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Ostrowski M.C."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Sharma S.M."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Sharma S.M."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Bronisz A."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Bronisz A."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Tzivion G."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Tzivion G."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Godlewski J."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Godlewski J."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Mansky K.C."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/author | "Mansky K.C."xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/pages | "3897-3906"xsd:string |
| http://purl.uniprot.org/citations/16822840 | http://purl.uniprot.org/core/pages | "3897-3906"xsd:string |